Article
Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis.
Nature - 3 Sept 2015
Zhou Qiangjun, Lai Ying, Bacaj Taulant, Zhao Minglei, Lyubimov Artem Y, Uervirojnangkoorn Monarin, Zeldin Oliver B, Brewster Aaron S, Sauter Nicholas K, Cohen Aina E, Soltis S Michael, Alonso-Mori Roberto, Chollet Matthieu, Lemke Henrik T, Pfuetzner Richard A, Choi Ucheor B, Weis William I, Diao Jiajie, Südhof Thomas C, Brunger Axel T
Abstract excerpt
Synaptotagmin-1 and neuronal SNARE proteins have central roles in evoked synchronous neurotransmitter release; however, it is unknown how they cooperate to trigger synaptic vesicle fusion. Here we report atomic-resolution crystal structures of Ca(2+)- and Mg(2+)-bound complexes between synaptotagmin-1 and the neuronal SNARE complex, one of which was determined with diffraction data from an X-ray free-electron...
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