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Article

Synergistic roles of Synaptotagmin-1 and complexin in calcium-regulated neuronal exocytosis.

eLife - 13 May 2020

Ramakrishnan Sathish, Bera Manindra, Coleman Jeff, Rothman James E, Krishnakumar Shyam S

Abstract excerpt

Calcium (Ca2+)-evoked release of neurotransmitters from synaptic vesicles requires mechanisms both to prevent un-initiated fusion of vesicles (clamping) and to trigger fusion following Ca2+-influx. The principal components involved in these processes are the vesicular fusion machinery (SNARE proteins) and the regulatory proteins, Synaptotagmin-1 and Complexin. Here, we use a reconstituted single-vesicle fusion...

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Share to Adaptor Proteins, Vesicular Transport
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32401194
DOI: 10.7554/eLife.54506
PMCID: PMC7220375

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Synergistic roles of Synaptotagmin-1 and complexin in calcium-regulated neuronal exocytosis.PMID 32401194Read ↗

Molecular origins of synaptotagmin 1 activities on vesicle docking and fusion pore opening.Semantic proximity Read ↗

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Rapid and selective binding to the synaptic SNARE complex suggests a modulatory role of complexins in neuroexocytosis.Semantic proximity Read ↗

The primed SNARE-complexin-synaptotagmin complex for neuronal exocytosis.Semantic proximity Read ↗

Complexin inhibits spontaneous release and synchronizes Ca2+-triggered synaptic vesicle fusion by distinct mechanisms.Semantic proximity Read ↗

Synaptotagmin-Ca2+ triggers two sequential steps in regulated exocytosis in rat PC12 cells: fusion pore opening and fusion pore dilation.Semantic proximity Read ↗

Reconstitution of Ca2+-regulated membrane fusion by synaptotagmin and SNAREs.Semantic proximity Read ↗

Binding of the complexin N terminus to the SNARE complex potentiates synaptic-vesicle fusogenicity.Semantic proximity Read ↗

Reconstituted synaptotagmin I mediates vesicle docking, priming, and fusion.Semantic proximity Read ↗

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Complexin Binding to Membranes and Acceptor t-SNAREs Explains Its Clamping Effect on Fusion.Semantic proximity Read ↗

Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis.Semantic proximity Read ↗

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