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Article

Conformational dynamics of calcium-triggered activation of fusion by synaptotagmin.

Biophysical journal - 3 Dec 2013

Krishnakumar Shyam S, Kümmel Daniel, Jones Sunny J, Radoff Daniel T, Reinisch Karin M, Rothman James E

Abstract excerpt

Synaptotagmin triggers rapid exocytosis of neurotransmitters from synaptic vesicles in response to Calcium (Ca(2+)) ions. Here, we use a novel Nanodisc-based system, designed to be a soluble mimetic of the clamped synaptic vesicle-bilayer junction, combined with fluorescence resonance energy transfer (FRET) spectroscopy to monitor the structural relationships among SNAREs (soluble N-ethylmaleimide-sensitive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Synaptosomal-Associated Protein 25

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Source

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Identifiers

PMID: 24314081
DOI: 10.1016/j.bpj.2013.10.029
PMCID: PMC3853086

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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