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Article

MST4 kinase phosphorylates ACAP4 protein to orchestrate apical membrane remodeling during gastric acid secretion.

The Journal of biological chemistry - 29 Sept 2017

Yuan Xiao, Yao Phil Y, Jiang Jiying, Zhang Yin, Su Zeqi, Yao Wendy, Wang Xueying, Gui Ping, Mullen McKay, Henry Calmour, Ward Tarsha, Wang Wenwen, Brako Larry, Tian Ruijun, Zhao Xuannv, Wang Fengsong, Cao Xinwang, Wang Dongmei, Liu Xing, Ding Xia, Yao Xuebiao

Abstract excerpt

Digestion in the stomach depends on acidification of the lumen. Histamine-elicited acid secretion is triggered by activation of the PKA cascade, which ultimately results in the insertion of gastric H,K-ATPases into the apical plasma membranes of parietal cells. Our recent study revealed the functional role of PKA-MST4-ezrin signaling axis in histamine-elicited acid secretion. However, it remains uncharacterized...

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Identifiers

PMID: 28808054
DOI: 10.1074/jbc.M117.808212
PMCID: PMC5625048

Genes

ARF6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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