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Article

A low amino acid environment promotes cell macropinocytosis through the YY1-FGD6 axis in Ras-mutant pancreatic ductal adenocarcinoma.

Oncogene - 1 Feb 2022

Zhang Yi-Fan, Li Qing, Huang Pei-Qi, Su Tong, Jiang Shu-Heng, Hu Li-Peng, Zhang Xue-Li, Sun Yue, Pan Hong, Yang Xiao-Mei, Li Jun, Gai Yan-Zhi, Zhu Lei, Yao Lin-Li, Li Dong-Xue, Sun Yong-Wei, Zhang Zhi-Gang, Liu De-Jun, Zhang Yan-Li, Nie Hui-Zhen

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC), cancer with a high mortality rate and the highest rate of KRAS mutation, reportedly internalizes proteins via macropinocytosis to adapt to low amino acid levels in the tumor microenvironment. Here, we aimed to identify a key regulator of macropinocytosis for the survival of tumor cells in a low amino acid environment in PDAC. FYVE, RhoGEF, and PH domain-containing protein...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 35082383
DOI: 10.1038/s41388-021-02159-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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