Article

Galectin-8 regulates primary cilium in hypothalamic neurons through an L-type calcium channel/Aurora kinase A/HDAC6 pathway impacting body energy balance

2026-04-11

Abstract excerpt

<h4>ABSTRACT</h4> <h4>OBJETIVE</h4> Food intake, energy expenditure, and metabolic homeostasis depend on hypothalamic neurons’ responses to peripheral signals, such as leptin, involving the primary cilium (PC). The PC is crucial for signal transduction and is dynamically regulated by assembly/disassembly or reabsorption of its microtubules-based axoneme. Absence or reduction in the length of PC is associated wit...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 426d0420-c76a-529a-92a1-cc4e335a5b14
DOI: 10.64898/2026.04.09.716665

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Galectin-8 regulates primary cilium in hypothalamic neurons through an L-type calcium channel/Aurora kinase A/HDAC6 pathway impacting body energy balanceDOI 10.64898/2026.04.09.716665Read

Proximity proteomics of primary cilia in human hypothalamic neuronsSemantic proximity Read

BBSome: An essential component of hypothalamic regulation of energy homeostasisSemantic proximity Read

Neuronal cilia in energy homeostasisSemantic proximity Read

Cilia, Alström syndrome--molecular mechanisms and therapeutic perspectives.Semantic proximity Read

Neuropeptide Y Family Receptors Traffic via the Bardet-Biedl Syndrome Pathway to Signal in Neuronal Primary CiliaSemantic proximity Read

Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesitySemantic proximity Read

The role of primary cilia in obesity and diabetesSemantic proximity Read

Neuronal Cilia: Another Player in the Melanocortin System.Semantic proximity Read

Rediscovering Primary Cilia in Pancreatic IsletsSemantic proximity Read

Role of cilia in normal pancreas function and in diseased statesSemantic proximity Read

Neurodevelopmental disease mechanisms, primary cilia, and endosomes converge on the BLOC‐1 and BORC complexesSemantic proximity Read

Ciliary sensing in tanycytes couples nutrient availability to metabolic regulationSemantic proximity Read