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Article

PINK1 positively regulates HDAC3 to suppress dopaminergic neuronal cell death

9 Oct 2014

Abstract excerpt

Deciphering the molecular basis of neuronal cell death is a central issue in the etiology of neurodegenerative diseases, such as Parkinson's and Alzheimer's. Dysregulation of p53 levels has been implicated in neuronal apoptosis. The role of histone deacetylase 3 (HDAC3) in suppressing p53-dependent apoptosis has been recently emphasized; however, the molecular basis of modulation of p53 function by HDAC3 remains...

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PMID: 25305081
DOI: 10.1093/hmg/ddu526

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