Back to search

Article

Ubiquitin-specific protease 20 promotes CCCP-induced mitophagy through deubiquitination and stabilization of serine/threonine protein kinase PINK1

2025-03-31

Abstract excerpt

While Parkinson’s disease (PD) is predominantly sporadic, various mutations in the PTEN-induced putative kinase 1 (PINK1) gene have been linked to the autosomal recessive form of PD. PINK1, a serine/threonine protein kinase, holds a pivotal role in mitophagy - a process that selectively eliminates damaged mitochondria, overseeing mitochondrial quality control and ultimately safeguarding against neuronal cell loss...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
c693bd84-7466-54c7-928a-6f935aeaf495
DOI
10.1101/2025.03.30.646148
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Ubiquitin-specific protease 20 promotes CCCP-induced mitophagy through deubiquitination and stabilization of serine/threonine protein kinase PINK1DOI 10.1101/2025.03.30.646148
Molecular Symphony of Mitophagy: Ubiquitin‐Specific Protease‐30 as a Maestro for Precision Management of Neurodegenerative DiseasesSemantic proximity
Ubiquitin phosphorylation in Parkinson’s disease: Implications for pathogenesis and treatmentSemantic proximity
The emerging multifaceted role of PINK1 in cancer biologySemantic proximity
A novel USP30 inhibitor recapitulates genetic loss of USP30 and sets the trigger for PINK1-PARKIN amplification of mitochondrial ubiquitylationSemantic proximity
Characterising the function of the mitochondrial deubiquitylase USP30 in mitophagySemantic proximity
Identification of deubiquitylases involved in Parkin-mediated mitophagySemantic proximity
Molecular mechanisms of PINK1-related neurodegeneration.Semantic proximity
PINK1 and Parkin: emerging themes in mitochondrial homeostasisSemantic proximity
PINK1 and Parkin – mitochondrial interplay between phosphorylation and ubiquitylation in Parkinson's disease.Semantic proximity
USP30 inhibition induces mitophagy and reduces oxidative stress in parkin-deficient human neuronsSemantic proximity
PINK1/PARKIN signalling in neurodegeneration and neuroinflammationSemantic proximity
Therapeutic approaches to enhance PINK1/Parkin mediated mitophagy for the treatment of Parkinson’s diseaseSemantic proximity
Select a neighboring publication to make it the new centre.