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Article

Effect of gene-gene and gene-environment interactions associated with antituberculosis drug-induced hepatotoxicity.

Pharmacogenetics and genomics - 1 Oct 2017

Chamorro Julián G, Castagnino Jorge P, Aidar Omar, Musella Rosa M, Frías Ana, Visca Mabel, Nogueras Mabel, Costa Lucas, Perez Alessandro, Caradonna Fabio, de Larrañaga Gabriela F

Abstract excerpt

OBJECTIVES: This study evaluated the association between environmental factors and genetic variations in enzymes that metabolize antituberculosis (anti-TB) drugs [arylamine N-acetyltransferase 2, cytochrome P450 2E1 (CYP2E1), glutathione S-transferase theta 1 (GSTT1), and glutathione S-transferase mu 1] with antituberculosis drug-induced hepatotoxicity (ATDH). We also investigated the potential gene-gene and...

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Identifiers

PMID: 28799976
DOI: 10.1097/FPC.0000000000000300

Genes

GSTT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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