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Article

Risk factors of isoniazid-induced hepatotoxicity in Tunisian tuberculosis patients.

The pharmacogenomics journal - 1 Jul 2017

Ben Fredj N, Gam R, Kerkni E, Chaabane A, Chadly Z, Boughattas N, Aouam K

Abstract excerpt

Previous studies have shown controversial results on whether acetylator status causes isoniazid-induced hepatotoxicity (IIH). Moreover, the contribution of CYP2E1, a hepatic enzyme implicated in the formation of hepatotoxins, to the risk of developing IIH remains unclear. The objectives of this study were (i) to assess the quantitative relationship between the level of isoniazid serum concentration and the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27089936
DOI: 10.1038/tpj.2016.26

Genes

NAT2

Provenance

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