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Article

Role of polymorphic N-acetyl transferase2 and cytochrome P4502E1 gene in antituberculosis treatment-induced hepatitis.

Journal of gastroenterology and hepatology - 1 Feb 2011

Bose Purabi Deka, Sarma Manash Pratim, Medhi Subhash, Das Bhudev Chandra, Husain Syed Akhtar, Kar Premashis

Abstract excerpt

BACKGROUND AND AIM: Antituberculosis drugs, isoniazid and rifampicin, in combination, are known to develop drug-induced hepatotoxicity (DIH). A higher risk of DIH during antituberculosis treatment (ATT) has been reported in the Indian subcontinent compared to its Western counterparts. The role of genetic factors in a higher incidence of ATT hepatotoxicity in the Indian population is still unclear. The present...

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Share to Acetylation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Arylamine N-Acetyltransferase

Share to Chemical and Drug Induced Liver Injury

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Source

Identifiers

PMID: 21261721
DOI: 10.1111/j.1440-1746.2010.06355.x

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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