Article
Genetic interaction between NAT2, GSTM1, GSTT1, CYP2E1, and environmental factors is associated with adverse reactions to anti-tuberculosis drugs.
Molecular diagnosis & therapy - 1 Aug 2012
Costa Gustavo N O, Magno Luiz A V, Santana Cinthia V N, Konstantinovas Cibele, Saito Samuel T, Machado Moara, Di Pietro Giuliano, Bastos-Rodrigues Luciana, Miranda Débora M, De Marco Luiz A, Romano-Silva Marco A, Rios-Santos Fabrício
Abstract excerpt
BACKGROUND: Adverse drug reactions (ADRs) associated with anti-tuberculosis (anti-TB) drug regimens have considerable impact on anti-TB treatment, potentially leading to unsuccessful outcomes. Nevertheless, the risk factors that play a role in anti-TB drug-induced ADRs are not well established. It is well documented that genetic polymorphisms in drug-metabolizing enzymes (DMEs) result in considerably complex...
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