Article
Factors associated with anti-TB drug-induced hepatotoxicity and genetic polymorphisms in indigenous and non-indigenous populations in Brazil.
Tuberculosis (Edinburgh, Scotland) - 1 Dec 2016
Heinrich Melissa M, Zembrzuski Verônica M, Ota Marcos M, Sacchi Flavia P, Teixeira Raquel L F, Cabello Acero Pedro H, Cunha Geraldo Marcelo, Souza-Santos Reinaldo, Croda Julio, Basta Paulo C
Abstract excerpt
Anti-tuberculosis (TB) drugs are responsible for the occurrence of several adverse drug reactions (ADRs), including hepatotoxicity. The aim was to estimate the incidence of hepatotoxicity and its association with genetic polymorphisms and clinical-epidemiological factors by comparing indigenous and non-indigenous TB patients. We investigated clinical-epidemiological variables, serum levels of liver enzymes and...
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