Article
Sex, ethnicity, and slow acetylator profile are the major causes of hepatotoxicity induced by antituberculosis drugs.
Journal of gastroenterology and hepatology - 1 Feb 2013
Chamorro Julián G, Castagnino Jorge P, Musella Rosa M, Nogueras Mabel, Aranda Federico M, Frías Ana, Visca Mabel, Aidar Omar, Perés Silvia, de Larrañaga Gabriela F
Abstract excerpt
BACKGROUND AND AIM: Treatment with antituberculosis (TB) drugs produces liver damage in a large proportion of patients. Isoniazid, an antibacterial drug, is primarily responsible for this hepatotoxicity. Several polymorphisms of the N-acetyltransferase 2 (NAT-2) and cytochrome P450 2E1 enzymes, which are involved in the metabolism of isoniazid, may be directly associated with the development of hepatotoxicity....
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