Article
NAT2 genetic polymorphisms and anti-tuberculosis drug-induced hepatotoxicity in Chinese community population.
Annals of hepatology - 1 Jan 2000
Lv Xiaozhen, Tang Shaowen, Xia Yinyin, Zhang Yuan, Wu Shanshan, Yang Zhirong, Li Xiaoting, Tu Dehua, Chen Yixin, Deng Peiyuan, Ma Yu, Chen Dafang, Chen Ru, Zhan Siyan
Abstract excerpt
BACKGROUND: Anti-tuberculosis drug-induced hepatotoxicity (ATDH) is one of the most prevalent and serious adverse drug reactions in the course of anti-tuberculosis (TB) treatment. Some researchers suggested that determination of N-acetyltransferase 2 (NAT2) genotype may be clinically useful to identify patients at high risk of developing ATDH. AIM: To evaluate whether the NAT2 genotype could be as a predictor for...
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