Activation-induced cytidine deaminase targets SUV4-20-mediated histone H4K20 trimethylation to class-switch recombination sites.

doi:10.1038/s41598-017-07380-9

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Article

Activation-induced cytidine deaminase targets SUV4-20-mediated histone H4K20 trimethylation to class-switch recombination sites.

Scientific reports - 8 Aug 2017

Rodríguez-Cortez Virginia C, Martínez-Redondo Paloma, Català-Moll Francesc, Rodríguez-Ubreva Javier, Garcia-Gomez Antonio, Poorani-Subramani Ganesh, Ciudad Laura, Hernando Henar, Pérez-García Arantxa, Company Carlos, Urquiza José M, Ramiro Almudena R, Di Noia Javier M, Vaquero Alejandro, Ballestar Esteban

Abstract excerpt

Activation-induced cytidine deaminase (AID) triggers antibody diversification in B cells by catalysing deamination and subsequently mutating immunoglobulin (Ig) genes. Association of AID with RNA Pol II and occurrence of epigenetic changes during Ig gene diversification suggest participation of AID in epigenetic regulation. AID is mutated in hyper-IgM type 2 (HIGM2) syndrome. Here, we investigated the potential...

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PMID: 28790320
DOI: 10.1038/s41598-017-07380-9
PMCID: PMC5548798

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Activation-induced cytidine deaminase targets SUV4-20-mediated histone H4K20 trimethylation to class-switch recombination sites.PMID 28790320Read ↗

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A Hyper-IgM Syndrome Mutation in Activation-Induced Cytidine Deaminase Disrupts G-Quadruplex Binding and Genome-wide Chromatin Localization.Semantic proximity Read ↗

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