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Article

The polarity protein partitioning-defective 1 (PAR-1) regulates dendritic spine morphogenesis through phosphorylating postsynaptic density protein 95 (PSD-95).

The Journal of biological chemistry - 31 Aug 2012

Wu Qian, DiBona Victoria L, Bernard Laura P, Zhang Huaye

Abstract excerpt

The polarity protein PAR-1 plays an essential role in many cellular contexts, including embryogenesis, asymmetric cell division, directional migration, and epithelial morphogenesis. Despite its known importance in different cellular processes, the role of PAR-1 in neuronal morphogenesis is less well understood. In particular, its role in the morphogenesis of dendritic spines, which are sites of excitatory...

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Identifiers

PMID: 22807451
DOI: 10.1074/jbc.M112.351452
PMCID: PMC3436321

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PSD

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Related research

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The polarity protein partitioning-defective 1 (PAR-1) regulates dendritic spine morphogenesis through phosphorylating postsynaptic density protein 95 (PSD-95).PMID 22807451Read ↗

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Microtubule affinity-regulating kinase 2 functions downstream of the PAR-3/PAR-6/atypical PKC complex in regulating hippocampal neuronal polarity.Semantic proximity Read ↗

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Casein kinase 2 phosphorylation of protein kinase C and casein kinase 2 substrate in neurons (PACSIN) 1 protein regulates neuronal spine formation.Semantic proximity Read ↗

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