Article
Palmitoylation regulates glutamate receptor distributions in postsynaptic densities through control of PSD95 conformation and orientation.
Proceedings of the National Academy of Sciences of the United States of America - 27 Dec 2016
Jeyifous Okunola, Lin Eric I, Chen Xiaobing, Antinone Sarah E, Mastro Ryan, Drisdel Renaldo, Reese Thomas S, Green William N
Abstract excerpt
Postsynaptic density protein 95 (PSD95) and synapse-associated protein 97 (SAP97) are homologous scaffold proteins with different N-terminal domains, possessing either a palmitoylation site (PSD95) or an L27 domain (SAP97). Here, we measured PSD95 and SAP97 conformation in vitro and in postsynaptic densities (PSDs) using FRET and EM, and examined how conformation regulated interactions with AMPA-type and...
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