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Article

Probing the interaction of the p53 C-terminal domain to the histone demethylase LSD1.

Archives of biochemistry and biophysics - 15 Oct 2017

Speranzini Valentina, Ciossani Giuseppe, Marabelli Chiara, Mattevi Andrea

Abstract excerpt

The p53 transcription factor plays a central role in the regulation of the expression of several genes, and itself is post-translationally regulated through its different domains. Of particular relevance for p53 function is its intrinsically disordered C-terminal domain (CTD), representing a hotspot for post-translational modifications and a docking site for transcriptional regulators. For example, the histone H3...

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PMID: 28784588
DOI: 10.1016/j.abb.2017.07.021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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