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Article

Molecular basis of the interactions between the p73 N terminus and p300: effects on transactivation and modulation by phosphorylation.

Proceedings of the National Academy of Sciences of the United States of America - 3 Mar 2009

Burge Sarah, Teufel Daniel P, Townsley Fiona M, Freund Stefan M V, Bycroft Mark, Fersht Alan R

Abstract excerpt

The transcription factor p73 belongs to the p53 family of proteins and can transactivate a number of target genes in common with p53. Here, we characterized the interaction of the p73 N terminus with four domains of the transcriptional coactivator p300 and with the negative regulator Mdm2 by using biophysical and cellular measurements. We found that, like p53, the N terminus of p73 contained two distinct...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19218448
DOI: 10.1073/pnas.0900383106
PMCID: PMC2651247

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Molecular basis of the interactions between the p73 N terminus and p300: effects on transactivation and modulation by phosphorylation.PMID 19218448Read ↗

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