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Article

The p53 tetramer shows an induced-fit interaction of the C-terminal domain with the DNA-binding domain.

Oncogene - 23 Jun 2016

D'Abramo M, Bešker N, Desideri A, Levine A J, Melino G, Chillemi G

Abstract excerpt

The Trp53 gene is the most frequently mutated gene in all human cancers. Its protein product p53 is a very powerful transcription factor that can activate different biochemical pathways and affect the regulation of metabolism, senescence, DNA damage response, cell cycle and cell death. The understanding of its function at the molecular level could be of pivotal relevance for therapy. Investigation of long-range...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26477317
DOI: 10.1038/onc.2015.388
PMCID: PMC4929483

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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