Article
Binding of Rad51 and other peptide sequences to a promiscuous, highly electrostatic binding site in p53.
The Journal of biological chemistry - 4 Mar 2005
Friedler Assaf, Veprintsev Dmitry B, Rutherford Trevor, von Glos Karoly I, Fersht Alan R
Abstract excerpt
Homologous recombination is repressed by the binding of p53 to Rad51. We identified by fluorescence and NMR spectroscopy that peptides corresponding to residues 179-190 of Rad51 bind to the core domain of p53 in a site that overlaps with its specific DNA binding site. The p53 site is quite promiscuous, since it also binds peptides derived from 53BP1, 53BP2, Hif-1alpha, and BCL-X(L) in overlapping regions. Binding...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.