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Article

Differences in the transactivation domains of p53 family members: a computational study.

BMC genomics - 10 Feb 2010

Mavinahalli Jagadeesh N, Madhumalar Arumugam, Beuerman Roger W, Lane David P, Verma Chandra

Abstract excerpt

The N terminal transactivation domain of p53 is regulated by ligases and coactivator proteins. The functional conformation of this region appears to be an alpha helix which is necessary for its appropriate interactions with several proteins including MDM2 and p300. Folding simulation studies have...

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Share to Hydrophobic and Hydrophilic Interactions
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20158876
DOI: 10.1186/1471-2164-11-S1-S5
PMCID: PMC2822533

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20158876-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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