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Article

Sequence-dependent cooperative binding of p53 to DNA targets and its relationship to the structural properties of the DNA targets

10 Nov 2010

Abstract excerpt

The prime mechanism by which p53 acts as a tumor suppressor is as a transcription factor regulating the expression of diverse downstream genes. The DNA-binding domain of p53 (p53DBD) interacts with defined DNA sites and is the main target for mutations in human primary tumors. Here, we show that the CWWG motif, found in the center of each consensus p53 half-site, is a key player in p53/DNA interactions....

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PMID: 21071400
DOI: 10.1093/nar/gkq1044

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