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Article

Comparison of the structures and peptide binding specificities of the BRCT domains of MDC1 and BRCA1.

Structure (London, England : 1993) - 10 Feb 2010

Campbell Stephen J, Edwards Ross A, Glover J N Mark

Abstract excerpt

The tandem BRCT domains of BRCA1 and MDC1 facilitate protein signaling at DNA damage foci through specific interactions with serine-phosphorylated protein partners. The MDC1 BRCT binds pSer-Gln-Glu-Tyr-COO(-) at the C terminus of the histone variant gammaH2AX via direct recognition of the C-terminal carboxylate, while BRCA1 recognizes pSer-X-X-Phe motifs either at C-terminal or internal sites within target...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20159462
DOI: 10.1016/j.str.2009.12.008

Genes

MDC1
BRCA1

Provenance

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