Article
Association Between Polymorphisms of the Mannose-Binding Lectin and Severity of Periportal Fibrosis in Schistosomiasis, in the Northeast of Brazil.
Genetic testing and molecular biomarkers - 1 Sept 2017
da Silva Constantino Taynan, de Lima Elker Lene Santos, de Brito Lidiane Régia Pereira Braga, Silva Jamile Luciana, Coêlho Maria Rosângela Cunha Duarte, Muniz Maria Tereza Cartaxo, Silva Paula Carolina Valença, Domingues Ana Lúcia Coutinho
Abstract excerpt
AIMS: Mannose-binding lectin (MBL) is a protein synthesized by the liver and its immune response is associated with the development of liver fibrosis. We hypothesized that the polymorphisms in the Exon 1 region (52, 54, 57) and promoter regions (-550 H/L, -221 X/Y) of the MBL2 gene were associated with the severity of periportal fibrosis (PPF), and that these polymorphisms affect the MBL serum levels. MATERIALS...
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