Article
Association of the polymorphism Exon 1 (A/O) region of the mannose-binding lectin gene and periportal fibrosis regression in schistosomiasis after specific treatment.
Revista da Sociedade Brasileira de Medicina Tropical - 1 Jan 2020
Oliveira Saulo Gomes de, Souza Ilana Brito Ferraz de, Constantino Taynan da Silva, Silva Paula Carolina Valença, Lima Elker Lene Santos de, Muniz Maria Tereza Cartaxo, Domingues Ana Lúcia Coutinho
Abstract excerpt
INTRODUCTION: We evaluated the association between genetic polymorphisms in exon 1 (A/O alleles) and promoter regions at positions -550 (H/L variant, rs11003125) and -221 (X/Y variant, rs7096206) MBL2 and periportal fibrosis regression. METHODS: This was a retrospective cohort study involving 114 Brazilians infected with Schistosoma mansoni, who were subjected to follow-up for three years after specific treatment...
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