Article
Association of SNP (-G1082A) IL-10 with increase in severity of periportal fibrosis in schistosomiasis, in the northeast of Brazil.
Genetic testing and molecular biomarkers - 1 Sept 2014
Silva Paula Carolina Valença, Gomes Adriana Vieira, de Souza Tayllanne Karina Gomes, Coêlho Maria Rosângela Cunha Duarte, Cahu Georgea Gertrudes de Oliveira Mendes, Muniz Maria Tereza Cartaxo, Domingues Ana Lúcia Coutinho
Abstract excerpt
Interleukin 10 (IL-10) is an important anti-inflammatory cytokine that modulates severe periportal fibrosis (PPF). We hypothesized that genetic polymorphisms (-G1082A/-C819T/-C592A) of the IL-10 gene and classic factors (age, sex, alcohol, exposure, and specific treatment) are associated with the severity of PPF and that these polymorphisms influence IL-10 expression. In this cross-sectional study, we genotyped...
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