CXCL12 drives natural variation in coronary artery anatomy across diverse populations.

doi:10.1016/j.cell.2025.02.005

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Article

CXCL12 drives natural variation in coronary artery anatomy across diverse populations.

Cell - 3 Apr 2025

Rios Coronado Pamela E, Zhou Jiayan, Fan Xiaochen, Zanetti Daniela, Naftaly Jeffrey A, Prabala Pratima, Martínez Jaimes Azalia M, Farah Elie N, Kundu Soumya, Deshpande Salil S, Evergreen Ivy, Kho Pik Fang, Ma Qixuan, Hilliard Austin T, Abramowitz Sarah, Pyarajan Saiju, Dochtermann Daniel, Damrauer Scott M, Chang Kyong-Mi, Levin Michael G, Winn Virginia D, Paşca Anca M, Plomondon Mary E, Waldo Stephen W, Tsao Philip S, Kundaje Anshul, Chi Neil C, Clarke Shoa L, Red-Horse Kristy, Assimes Themistocles L

Abstract excerpt

Coronary arteries have a specific branching pattern crucial for oxygenating heart muscle. Among humans, there is natural variation in coronary anatomy with respect to perfusion of the inferior/posterior left heart, which can branch from either the right arterial tree, the left, or both-a phenotype known as coronary dominance. Using angiographic data for >60,000 US veterans of diverse ancestry, we conducted a...

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PMID: 40049164
DOI: 10.1016/j.cell.2025.02.005
PMCID: PMC12029448

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CXCL12

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