Article

A GATA2-PROX1-FOXC2 regulatory axis integrates shear stress signaling with lymphatic vascular development

2026-06-26

Abstract excerpt

<h4>ABSTRACT</h4> The two-hit hypothesis provides a novel framework for incompletely penetrant vascular disorders. Emberger syndrome, caused by heterozygous loss-of-function mutations in mechanosensitive transcription factor (TF) GATA2, is associated with lymphedema in a subset of patients, suggesting that modifiers influence disease development. Heterozygous loss-of-function mutations in mechanosensitive TF FOXC...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5d7f0c53-b54c-56b1-a943-85f3b7284edb
DOI: 10.64898/2026.06.25.734612

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A GATA2-PROX1-FOXC2 regulatory axis integrates shear stress signaling with lymphatic vascular developmentDOI 10.64898/2026.06.25.734612Read

GATA2 is required for lymphatic vessel valve development and maintenance.Semantic proximity Read

FOXC2 and fluid shear stress stabilize postnatal lymphatic vasculatureSemantic proximity Read

ORAI1 Activates Proliferation of Lymphatic Endothelial Cells in Response to Laminar Flow Through Krüppel-Like Factors 2 and 4.Semantic proximity Read

Lymph flow regulates collecting lymphatic vessel maturation in vivoSemantic proximity Read

Hdac3 regulates lymphovenous and lymphatic valve formationSemantic proximity Read

Complementary Wnt Sources Regulate Lymphatic Vascular Development via PROX1-Dependent Wnt/β-Catenin SignalingSemantic proximity Read

GATA2 controls lymphatic endothelial cell junctional integrity and lymphovenous valve morphogenesis through <i>miR-126</i>Semantic proximity Read

CXCL12/CXCR4 Governs Lymphatic Valve Formation Through Flow Dependent AKT/FOXO1/FOXC2 ActivationSemantic proximity Read

The Transcriptional Control of Lymphatic Vascular DevelopmentSemantic proximity Read

Lymphatic vessel development: fluid flow and valve-forming cells.Semantic proximity Read

Distinct topologically associated domains underlie regulatory logic in lymphatic endothelial cells contributing to proper cell differentiationSemantic proximity Read

TIE1-dependent lymphatic vascular remodeling is mediated by its second tyrosine kinase domainSemantic proximity Read