Article
Chronic SR Ca2+-ATPase inhibition causes adaptive changes in cellular Ca2+ transport.
Circulation research - 18 Apr 2003
Brittsan Angela G, Ginsburg Kenneth S, Chu Guoxiang, Yatani Atsuko, Wolska Beata M, Schmidt Albrecht G, Asahi Michio, MacLennan David H, Bers Donald M, Kranias Evangelia G
Abstract excerpt
Phospholamban, the critical regulator of the cardiac SERCA2a Ca2+ affinity, is phosphorylated at Ser16 and Thr17 during beta-adrenergic stimulation (eg, isoproterenol). To assess the impact of nonphosphorylatable phospholamban, a S16A, T17A double-mutant (DM) was introduced into phospholamban knockout mouse hearts. Transgenic lines expressing DM phospholamban at levels similar to wild types (WT) were identified....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.