Article
Chronic SR Ca2+-ATPase inhibition causes adaptive changes in cellular Ca2+ transport.
Circulation research - 18 Apr 2003
Brittsan Angela G, Ginsburg Kenneth S, Chu Guoxiang, Yatani Atsuko, Wolska Beata M, Schmidt Albrecht G, Asahi Michio, MacLennan David H, Bers Donald M, Kranias Evangelia G
Abstract excerpt
Phospholamban, the critical regulator of the cardiac SERCA2a Ca2+ affinity, is phosphorylated at Ser16 and Thr17 during beta-adrenergic stimulation (eg, isoproterenol). To assess the impact of nonphosphorylatable phospholamban, a S16A, T17A double-mutant (DM) was introduced into phospholamban knockout mouse hearts. Transgenic lines expressing DM phospholamban at levels similar to wild types (WT) were identified....
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