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Article

SMUG1 is able to excise uracil from immunoglobulin genes: insight into mutation versus repair.

The EMBO journal - 8 Feb 2006

Di Noia Javier M, Rada Cristina, Neuberger Michael S

Abstract excerpt

Mammals harbour multiple enzymes capable of excising uracil from DNA, although their distinct physiological roles remain uncertain. One of them (UNG) plays a critical role in antibody gene diversification, as UNG deficiency alone is sufficient to perturb the process. Here, we show this unique requirement for UNG does not reflect the fact that other glycosylases are unable to access the U:G lesion. SMUG1, if...

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Share to Antibody Diversity
Share to B-Lymphocytes
Share to DNA Replication

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Immunoglobulin

Share to Immunoglobulin Isotypes

Share to Lymphocyte Activation

Share to Uracil

Share to Uracil-DNA Glycosidase

Source

Open in PubMed Open full text

Identifiers

PMID: 16407970
DOI: 10.1038/sj.emboj.7600939
PMCID: PMC1383525

Genes

SMUG1
UNG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

SMUG1 is able to excise uracil from immunoglobulin genes: insight into mutation versus repair.PMID 16407970Read ↗

Uracil excision by endogenous SMUG1 glycosylase promotes efficient Ig class switching and impacts on A:T substitutions during somatic mutation.Semantic proximity Read ↗

Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1.Semantic proximity Read ↗

Uracil-DNA glycosylase in base excision repair and adaptive immunity: species differences between man and mouse.Semantic proximity Read ↗

Pms2 and uracil-DNA glycosylases act jointly in the mismatch repair pathway to generate Ig gene mutations at A-T base pairs.Semantic proximity Read ↗

Refining the Neuberger model: Uracil processing by activated B cells.Semantic proximity Read ↗

Dependence of antibody gene diversification on uracil excision.Semantic proximity Read ↗

B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil.Semantic proximity Read ↗

Further evidence for involvement of a noncanonical function of uracil DNA glycosylase in class switch recombination.Semantic proximity Read ↗

UNG shapes the specificity of AID-induced somatic hypermutation.Semantic proximity Read ↗

Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung-/-Msh2-/- mice.Semantic proximity Read ↗

Structure and specificity of the vertebrate anti-mutator uracil-DNA glycosylase SMUG1.Semantic proximity Read ↗

Known components of the immunoglobulin A:T mutational machinery are intact in Burkitt lymphoma cell lines with G:C bias.Semantic proximity Read ↗

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