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Article

Refining the Neuberger model: Uracil processing by activated B cells.

European journal of immunology - 1 Jul 2014

Maul Robert W, Gearhart Patricia J

Abstract excerpt

During the immune response, B cells undergo a programed mutagenic cascade to promote increased affinity and expanded antibody function. The two processes, somatic hypermutation (SHM) and class switch recombination (CSR), are initiated by the protein activation-induced deaminase (AID), which converts cytosine to uracil in the immunoglobulin loci. The presence of uracil in DNA promotes DNA mutagenesis though a...

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Share to MSH2 gene
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24920531
DOI: 10.1002/eji.201444813
PMCID: PMC4126077

Genes

SMUG1
UNG
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

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Research trail→

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Refining the Neuberger model: Uracil processing by activated B cells.PMID 24920531Read ↗

SMUG1 is able to excise uracil from immunoglobulin genes: insight into mutation versus repair.Semantic proximity Read ↗

Uracil-DNA glycosylase in base excision repair and adaptive immunity: species differences between man and mouse.Semantic proximity Read ↗

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Genomic Uracil Homeostasis during Normal B Cell Maturation and Loss of This Balance during B Cell Cancer DevelopmentSemantic proximity Read ↗

Mutating for Good: DNA Damage Responses During Somatic HypermutationSemantic proximity Read ↗

Error-free versus mutagenic processing of genomic uracil—Relevance to cancerSemantic proximity Read ↗

Pms2 and uracil-DNA glycosylases act jointly in the mismatch repair pathway to generate Ig gene mutations at A-T base pairs.Semantic proximity Read ↗

B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil.Semantic proximity Read ↗

UNG shapes the specificity of AID-induced somatic hypermutation.Semantic proximity Read ↗

Uracil in DNA and its processing by different DNA glycosylasesSemantic proximity Read ↗

Base Excision Repair in the Immune System: Small DNA Lesions With Big ConsequencesSemantic proximity Read ↗

Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1.Semantic proximity Read ↗

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