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Article

Gene-targeted mice lacking the Ung uracil-DNA glycosylase develop B-cell lymphomas

21 Aug 2003

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Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 12934097
DOI: 10.1038/sj.onc.1206860

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Related research

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Gene-targeted mice lacking the Ung uracil-DNA glycosylase develop B-cell lymphomasPMID 12934097Read ↗

Uracil–DNA glycosylase UNG1 isoform variant supports class switch recombination and repairs nuclear genomic uracilSemantic proximity Read ↗

Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1.Semantic proximity Read ↗

Uracil-DNA glycosylase in base excision repair and adaptive immunity: species differences between man and mouse.Semantic proximity Read ↗

Deficiency in the DNA glycosylases UNG1 and OGG1 does not potentiate c-Myc-induced B-cell lymphomagenesis.Semantic proximity Read ↗

Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung-/-Msh2-/- mice.Semantic proximity Read ↗

Monoclonal B-cell hyperplasia and leukocyte imbalance precede development of B-cell malignancies in uracil-DNA glycosylase deficient mice.Semantic proximity Read ↗

SMUG1 is able to excise uracil from immunoglobulin genes: insight into mutation versus repair.Semantic proximity Read ↗

Genomic Uracil Homeostasis during Normal B Cell Maturation and Loss of This Balance during B Cell Cancer DevelopmentSemantic proximity Read ↗

Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability.Semantic proximity Read ↗

No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice.Semantic proximity Read ↗

Strikingly different properties of uracil-DNA glycosylases UNG2 and SMUG1 may explain divergent roles in processing of genomic uracilSemantic proximity Read ↗

Generation of a mouse model with down-regulated U50 snoRNA (SNORD50) expression and its organ-specific phenotypic modulation.Semantic proximity Read ↗

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