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Article

Uracil excision by endogenous SMUG1 glycosylase promotes efficient Ig class switching and impacts on A:T substitutions during somatic mutation.

European journal of immunology - 1 Jul 2014

Dingler Felix A, Kemmerich Kristin, Neuberger Michael S, Rada Cristina

Abstract excerpt

Excision of uracil introduced into the immunoglobulin loci by AID is central to antibody diversification. While predominantly carried out by the UNG uracil-DNA glycosylase as reflected by deficiency in immunoglobulin class switching in Ung(-/-) mice, the deficiency is incomplete, as evidenced by the emergence of switched IgG in the serum of Ung(-/-) mice. Lack of switching in mice deficient in both UNG and MSH2...

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Topics

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Share to Immunoglobulin A
Share to Immunoglobulin Class Switching

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin G

Share to Mutation

Share to MutS Homolog 2 Protein

Share to Uracil

Share to Uracil-DNA Glycosidase

Source

Open in PubMed Open full text

Identifiers

PMID: 24771041
DOI: 10.1002/eji.201444482
PMCID: PMC4158878

Genes

MSH2
SMUG1
UNG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Uracil excision by endogenous SMUG1 glycosylase promotes efficient Ig class switching and impacts on A:T substitutions during somatic mutation.PMID 24771041Read ↗

SMUG1 is able to excise uracil from immunoglobulin genes: insight into mutation versus repair.Semantic proximity Read ↗

Further evidence for involvement of a noncanonical function of uracil DNA glycosylase in class switch recombination.Semantic proximity Read ↗

UNG shapes the specificity of AID-induced somatic hypermutation.Semantic proximity Read ↗

Dependence of antibody gene diversification on uracil excision.Semantic proximity Read ↗

B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil.Semantic proximity Read ↗

Uracil-DNA glycosylase in base excision repair and adaptive immunity: species differences between man and mouse.Semantic proximity Read ↗

Refining the Neuberger model: Uracil processing by activated B cells.Semantic proximity Read ↗

Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1.Semantic proximity Read ↗

Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation.Semantic proximity Read ↗

The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2-/- ung-/- mice.Semantic proximity Read ↗

Pms2 and uracil-DNA glycosylases act jointly in the mismatch repair pathway to generate Ig gene mutations at A-T base pairs.Semantic proximity Read ↗

UNG protects B cells from AID-induced telomere lossSemantic proximity Read ↗

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