Article

α-Synuclein Strain Propagation is Independent of Cellular Prion Protein Expression in Transgenic Mice

2024-03-30

Abstract excerpt

The cellular prion protein, PrP C , has been postulated to function as a receptor for α-synuclein, potentially facilitating cell-to-cell spreading and/or toxicity of α-synuclein aggregates in neurodegenerative disorders such as Parkinson’s disease. To test this hypothesis, we compared the propagation behavior of two different α-synuclein aggregate strains in M83 transgenic mice that either expressed or did not ex...

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Literature Corpus work: be9db971-81e1-51d9-928b-03f3888e2407
DOI: 10.1101/2024.03.27.587028

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