Article
MED12 mutations and NOTCH signalling in chronic lymphocytic leukaemia.
British journal of haematology - 1 Nov 2017
Wu Bian, Słabicki Mikołaj, Sellner Leopold, Dietrich Sascha, Liu Xiyang, Jethwa Alexander, Hüllein Jennifer, Walther Tatjana, Wagner Lena, Huang Zhiqin, Zapatka Marc, Zenz Thorsten
Abstract excerpt
Mutations in the N-terminus of MED12 protein occur at high frequency in uterine leiomyomas and breast fibroepithelial tumours, and are frequently found in chronic lymphocytic leukaemia (CLL). MED12 mutations have been previously linked to aberrant Cyclin C-CDK8 kinase activity, but the exact oncogenic function in CLL is unknown. Here, we characterized MED12 mutations in CLL and identified recurrent mutations in...
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