Article
Somatic MED12 mutations are associated with poor prognosis markers in chronic lymphocytic leukemia.
Oncotarget - 30 Jan 2015
Kämpjärvi Kati, Järvinen Tiina M, Heikkinen Tuomas, Ruppert Amy S, Senter Leigha, Hoag Kevin W, Dufva Olli, Kontro Mika, Rassenti Laura, Hertlein Erin, Kipps Thomas J, Porkka Kimmo, Byrd John C, de la Chapelle Albert, Vahteristo Pia
Abstract excerpt
Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults. We performed systematic database search and identified highly specific MED12 mutations in CLL patients. To study this further, we collected three independent sample series comprising over 700 CLL samples and screened MED12 exons 1 and 2 by direct sequencing. Mutations were identified at significant frequency in all three series with a...
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