Article
High-throughput sequencing for the identification of NOTCH1 mutations in early stage chronic lymphocytic leukaemia: biological and clinical implications.
British journal of haematology - 1 Jun 2014
Lionetti Marta, Fabris Sonia, Cutrona Giovanna, Agnelli Luca, Ciardullo Carmela, Matis Serena, Ciceri Gabriella, Colombo Monica, Maura Francesco, Mosca Laura, Gentile Massimo, Recchia Anna G, Ilariucci Fiorella, Musolino Caterina, Molica Stefano, Di Raimondo Francesco, Cortelezzi Agostino, Rossi Davide, Gaidano Gianluca, Morabito Fortunato, Ferrarini Manlio, Neri Antonino
Abstract excerpt
NOTCH1 mutations have recently emerged as new genetic lesions significantly correlated with survival in chronic lymphocytic leukaemia (CLL). We performed deep next generation sequencing of the NOTCH1 mutation hotspot in 384 cases at diagnosis, including 100 monoclonal B cell lymphocytosis (MBL) and 284 Binet stage A CLL cases, enrolled in the Gruppo Italiano Studio Linfomi O-CLL1 multicentre trial. The NOTCH1...
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