Article
NOTCH1 mutations in +12 chronic lymphocytic leukemia (CLL) confer an unfavorable prognosis, induce a distinctive transcriptional profiling and refine the intermediate prognosis of +12 CLL.
Haematologica - 1 Mar 2012
Del Giudice Ilaria, Rossi Davide, Chiaretti Sabina, Marinelli Marilisa, Tavolaro Simona, Gabrielli Sara, Laurenti Luca, Marasca Roberto, Rasi Silvia, Fangazio Marco, Guarini Anna, Gaidano Gianluca, Foà Robin
Abstract excerpt
Trisomy 12, the third most frequent chromosomal aberration in chronic lymphocytic leukemia (CLL), confers an intermediate prognosis. In our cohort of 104 untreated patients carrying +12, NOTCH1 mutations occurred in 24% of cases and were associated to unmutated IGHV genes (P=0.003) and +12 as a s...
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