Article
A noncoding mutation in the NOTCH1 gene initiates oncogenic NOTCH signaling via wild-type NICD stabilization in CLL.
Blood - 16 Oct 2025
Guo Min, Memis Tugba, Ehrmann Alena Sophie, Pittrof Anselm, Baumann Bernd, Ferrante Francesca, Tausch Eugen, Fischer Kirsten, Döhner Hartmut, Borggrefe Tilman, Stilgenbauer Stephan, Pannicke Ulrich, Schwarz Klaus, Mertens Daniel, Oswald Franz
Abstract excerpt
ABSTRACT: Chronic lymphocytic leukemia (CLL) is the most common chronic blood cancer in adults. Active NOTCH signaling in CLL is associated with poorer prognosis. Importantly, patients with CLL with NOTCH1 noncoding mutations in the 3' untranslated region (3'UTR) manifested with a more aggressive disease course even compared with those with mutations in the NOTCH1 coding region. Here, we comprehensively...
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