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Breast cancer surgery in the era of genetic uncertainty: real-world outcomes in BRCA1/2 pathogenic variants and variants of uncertain significance.

BMC cancer - 13 Feb 2026

Ökten Ilker Nihat, Baydaş Tuba, Koca Sinan, Baltacı Mukaddes Feyza, Özen Filiz, Çil İbrahim, Eser Metin, Gündoğdu Adnan, Aktaş Merve, Yılmaz Osman Cem

Abstract excerpt

BACKGROUND: Germline testing for BRCA1 and BRCA2 has become integral to the management of breast cancer, with pathogenic variants strongly influencing surgical decision-making. However, the increasing detection of variants of uncertain significance (VUS) presents a major clinical challenge, as their implications for cancer risk and treatment remain unclear. This study aimed to evaluate real-world surgical...

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Identifiers

PMID: 41688965
DOI: 10.1186/s12885-026-15721-z
PMCID: PMC13011663

Genes

BRCA1
BRCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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