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Article

Clinical management among individuals with variant of uncertain significance in hereditary cancer: A systematic review and meta-analysis.

Clinical genetics - 1 Aug 2021

Makhnoon Sukh, Bednar Erica M, Krause Kate J, Peterson Susan K, Lopez-Olivo Maria A

Abstract excerpt

Improper medical use of variant of uncertain significance (VUS) remains a concern in hereditary cancer genetic testing. The goal of this study was to assess the association between pathogenic and likely pathogenic (P/LP), VUS, and benign and likely benign (B/LB) genetic test results and cancer-related surgical and screening management. Systematic searches of Medline, Embase, EBSCO CINAHL Plus, and PsycINFO were...

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Identifiers

PMID: 33843052
DOI: 10.1111/cge.13966
PMCID: PMC8672382

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