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Article

Impact of Multigene Panel Testing on Surgical Decision Making in Breast Cancer Patients.

Journal of the American College of Surgeons - 1 Apr 2018

Pederson Holly J, Gopalakrishnan Dharmesh, Noss Ryan, Yanda Courtney, Eng Charis, Grobmyer Stephen R

Abstract excerpt

BACKGROUND: With the advent of multigene panel testing for breast cancer patients, germline mutations with unknown association with cancer risk, known as variants of uncertain significance (VUS), are being increasingly identified. Some studies have shown higher rates of contralateral prophylactic mastectomies (CPM) in these patients, despite lack of evidence to support this intervention. We analyzed surgical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Fanconi Anemia Complementation Group N Protein

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Source

Identifiers

PMID: 29360614
DOI: 10.1016/j.jamcollsurg.2017.12.037

Genes

CPM
BRCA1
PALB2

Provenance

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