Clonal expansion of SIV-infected cells in macaques on antiretroviral therapy is similar to that of HIV-infected cells in humans

Abstract excerpt

Clonal expansion of HIV infected cells plays an important role in the formation and persistence of the reservoir that allows the virus to persist, in DNA form, despite effective antiretroviral therapy.We used integration site analysis to ask if there is a similar clonal expansion of SIV infected cells in macaques.We show that the distribution of HIV and SIV integration sites in vitro is similar and that both...

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