Article

Longitudinal clonal tracking in humanized mice reveals sustained polyclonal repopulation of gene-modified human-HSPC despite vector integration bias

2020-08-23

Abstract excerpt

<h4>Background</h4> Current understanding of hematopoiesis is largely derived from mouse models that are physiologically distant from humans. Humanized mice provide the most physiologically relevant small animal model to study human diseases, most notably preclinical gene-therapy studies. However, the clonal repopulation dynamics of human hematopoietic stem and progenitor cells (HSPC) in these animal models is on...

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Literature Corpus work: b7f8dffd-a861-5352-9720-41c1550be62c
DOI: 10.1101/2020.08.21.261537

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