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Article

Clonally expanded CD4 <sup>+</sup> T cells can produce infectious HIV-1 in vivo

8 Feb 2016

Abstract excerpt

Reservoirs of infectious HIV-1 persist despite years of combination antiretroviral therapy and make curing HIV-1 infections a major challenge. Most of the proviral DNA resides in CD4(+)T cells. Some of these CD4(+)T cells are clonally expanded; most of the proviruses are defective. It is not known if any of the clonally expanded cells carry replication-competent proviruses. We report that a highly expanded CD4(+)...

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PMID: 26858442
DOI: 10.1073/pnas.1522675113

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