Article

Tau pSer396 and pSer404 Define Distinct Epitope Regions Linked to Different Antibody Functions

2026-04-21

Abstract excerpt

Hyperphosphorylated tau is a central pathological feature of Alzheimer’s disease and related tauopathies, and antibodies targeting the pSer396/pSer404 epitope region represent a promising therapeutic strategy. However, direct comparisons of pSer396- and pSer404-selective antibodies and the impact of humanization on their functional properties remain limited. We generated two new monoclonal antibodies (mAbs), 9E (p...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a5549226-de12-5194-b20d-d152020841a9
DOI: 10.64898/2026.04.16.716390

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Tau pSer396 and pSer404 Define Distinct Epitope Regions Linked to Different Antibody FunctionsDOI 10.64898/2026.04.16.716390Read

Generation and characterization of new monoclonal antibodies targeting the PHF1 and AT8 epitopes on human tau.Semantic proximity Read

Tau Antibody Structure Reveals a Molecular Switch Defining a Pathological Conformation of the Tau ProteinSemantic proximity Read

Tau antibody chimerization alters its charge and binding, thereby reducing its cellular uptake and efficacySemantic proximity Read

Anti-tau VHH therapy against PHF6: a safe approach to slowing the phenotype of tau pathology.Semantic proximity Read

Tau‐targeting passive immunization modulates aspects of pathology in tau transgenic miceSemantic proximity Read

Highly specific and selective anti‐pS396‐tau antibody C10.2 targets seeding‐competent tauSemantic proximity Read

An effector-reduced anti-β-amyloid (Aβ) antibody with unique aβ binding properties promotes neuroprotection and glial engulfment of Aβ.Semantic proximity Read

Inhibition of tau neuronal internalization using anti-tau single domain antibodiesSemantic proximity Read

Anti-Tau VHH Therapy Against PHF6: A Safe Approach to Slowing the Phenotype of Tau PathologySemantic proximity Read

Passive Immunization with Phospho-Tau Antibodies Reduces Tau Pathology and Functional Deficits in Two Distinct Mouse Tauopathy ModelsSemantic proximity Read

CNS-Tau Specific Antibodies Illuminate Disease Signatures Across TauopathiesSemantic proximity Read

Structures of AT8 and PHF1 Phospho-Mimetic Tau: Insights Into the Posttranslational Modification Code of Tau Amyloid FormationSemantic proximity Read