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Article

Establishing a novel Pig-a gene mutation assay in L5178YTk+/- mouse lymphoma cells.

Environmental and molecular mutagenesis - 1 Jan 2018

Wang Yiying, Revollo Javier, McKinzie Page, Pearce Mason G, Dad Azra, Yucesoy Berran, Rosenfeldt Hans, Heflich Robert H, Dobrovolsky Vasily N

Abstract excerpt

The X-linked Pig-a gene encodes an enzyme required for the biosynthesis of glycosyl phosphatidylinositol (GPI) anchors. Pig-a mutant cells fail to synthesize GPI and to express GPI-anchored protein markers (e.g., CD90) on their surface. Marker deficiency serves as a phenotypic indicator of Pig-a mutation in various in vivo assays. Here, we describe an in vitro Pig-a mutation assay in L5178YTk+/- mouse lymphoma...

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PMID: 29098723
DOI: 10.1002/em.22152

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GPI

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