Article
Identification of a Genetic Variation in ERAP1 Aminopeptidase that Prevents Human Cytomegalovirus miR-UL112-5p-Mediated Immunoevasion.
Cell reports - 25 Jul 2017
Romania Paolo, Cifaldi Loredana, Pignoloni Benedetta, Starc Nadia, D'Alicandro Valerio, Melaiu Ombretta, Li Pira Giuseppina, Giorda Ezio, Carrozzo Rosalba, Bergvall Monika, Bergström Tomas, Alfredsson Lars, Olsson Tomas, Kockum Ingrid, Seppälä Ilkka, Lehtimäki Terho, Hurme Mikko A, Hengel Hartmut, Santoni Angela, Cerboni Cristina, Locatelli Franco, D'Amato Mauro, Fruci Doriana
Abstract excerpt
Herein, we demonstrate that HCMV miR-UL112-5p targets ERAP1, thereby inhibiting the processing and presentation of the HCMV pp65495-503 peptide to specific CTLs. In addition, we show that the rs17481334 G variant, naturally occurring in the ERAP1 3' UTR, preserves ERAP1 from miR-UL112-5p-mediated degradation. Specifically, HCMV miR-UL112-5p binds the 3' UTR of ERAP1 A variant, but not the 3' UTR of ERAP1 G...
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